Perhaps the interest you have in relocating has little to do with work and a lot to do with wanting a change in scenery. The fact is, even if your desire to relocate does stem from wanting a change in pace, employment definitely comes into play due to the importance that maintaining employment has to do with living life day to day. If finding work has you worried, don't let it. Another fact is that there are tips out there available to lead you in the right direction of finding proper employment no matter what region you hope to move to.
1. Make your resume available via job boards within the city and/or are you desire to move to.
Relocating does not guarantee that when you move to the area you will have a job waiting for you or that you will be contacted for a job. Allow your resume to be available through job boards so that hiring managers/recruiters can search through resume databases and know that you are willing to relocate for work.
2. Be knowledgeable of the adjustment that occurs with living costs.
Living in a high society like Manhattan probably cost significantly more than living in a small town in South Carolina. Of course, your salary may change in response to this change. Realize that this change is a distinct possibility and set expectations that are realistic when choosing what your salary range is for this new employment opportunity. Being realistic means you won't result in being priced out of the market.
3. Since relocation is what you want in your future, be open about it to the hiring manager/recruiter.
Whatever the reason may be, let your recruiter know. Be completely honest. If your reason is for higher salary, better career opportunities, or to move to be closer to your family, let them know. Even if your reasons are known of the above. Revealing that little detail can prove to be a hiring incentive because they see in you not only a qualified candidate, but someone who truly wants the job and needs the job.
4. Be open to relocating at your own expense.
Let's face it, when hiring, most recruiters or hiring managers prefer to hire local candidates over candidates looking to relocate for the sake of the position, especially because relocating is sometimes required to come out of the company's pocket. However, if you are willing to pay to relocate on your own expense and have a great resume, you have successfully upped your ante and made yourself as qualified for the position as local candidates.